Chronic Migraine is Associated with Reduced Corneal Nerve Fiber Density and Length

Activation of the trigeminal system is involved in migraine. Corneal nociceptive sensation is mediated by trigeminal axons that synapse in the Gasserian ganglion, brainstem, and serve sensory, protective, and trophic functions. In vivo Corneal Confocal Microscopy (ICCM) enables non-invasive imaging of the corneal sub-basal nerve plexus. We sought to determine if there are structural differences in the sub-basal corneal nerve plexus between chronic migraine patients and normal control participants using ICCM.