Orbital Fibroblasts From Thyroid Eye Disease Patients Differ In Proliferative And Adipogenic Responses Depending On Disease Sub-type

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Identifier 20140304_nanos_sciplatform2_04-1
Title Orbital Fibroblasts From Thyroid Eye Disease Patients Differ In Proliferative And Adipogenic Responses Depending On Disease Sub-type
Creator Ajay E. Kuriyan; Collynn F. Woeller; Charles W. O'Loughlin; Richard P. Phipps; Steven E. Feldon
Affiliation (AEK) (CFW) (SEF) University of Rochester Medical Center; (CWO) (RPP) University of Rochester Eye Institute
Subject Thyroid Eye Disease; Graves' Disease; Orbital Imaging; Adipogenesis; Cyclooxygenase Inhibitors
Description Thyroid Eye Disease (TED), an autoimmune process most frequently associated with Graves Disease, is the most common orbital disease. Orbital imaging can be used to classify TED patients as Type I (predominantly fat compartment enlargement) or Type II (predominantly extraocular muscle enlargement). In vitro, orbital fibroblasts (OFs) can be driven to differentiate into adipocytes or proliferate. We investigated whether Type I OFs undergo adipogenesis to a greater degree than Type II OFs, whereas Type II OFs undergo proliferation more than Type I OFs. We also studied the ability of cyclooxygenase (COX)-inhibitors to inhibit OF adipogenesis and proliferation.
Date 2014-03-04
Language eng
Format application/pdf
Format Creation Microsoft PowerPoint
Type Text
Source 2014 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS 2014: Scientific Platform Presentations (Session 2)
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Rights Management Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6d254cd
Context URL The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/
Setname ehsl_novel_nam
ID 183865
Reference URL https://collections.lib.utah.edu/ark:/87278/s6d254cd
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