Identifier |
19880222_nanos_regenphenomsympos_06 |
Title |
Axonal Regeneration and Synapse Formation in the Superior Colliculus by Retinal Ganglion Cells in the Adult Rat |
Creator |
Manuel Vidal-Sanz; Garth M. Bray; Maria P. Villegas Perez; Solon Thanos; Albert J. Aguayo |
Affiliation |
Neurosciences Unit, The Montreal General Hospital and McGill University, Montreal, Quebec H3G 1A4, Canada |
Subject |
Axons Physiology; Histocytochemistry; Fluorescence Microscopy; Nerve Regeneration; Retinal Ganglion Cells |
Description |
In adult rats, one optic nerve was transected and replaced by a 4 cm segment of autologous peropheral nerve (PN) that linked one eye and the superior colliculus (SC) along a predominantly extracranial course. Retrograde and orthograde studies with the tracers HRP or rhodamine-B-isothiocyanate (RITC), as well as immunocytochemical neuronal labels, indicated the following: (1) Regenerating axons from the axotomized retinal ganglion cells extended along the entire PN grafts, covering a distance nearly twice that of the normal retinotectal projection of intact rats. (2) Some of these axons penetrated SC and formed terminal arborizations up to 500um from the end of the graft. (3) By electron microscopy, the aborizations of these regerated axons in the SC were seen as small HRP-labeled axonal profiles that contacted neuronal processes in the SC; some of these contacts showed pre- and postsynaptic membrane specializations. These findings indicate that injured retinal ganglion cells in the adult rat are not only able to regrow lengthy axons, but may also form synapses in the SC. |
Date |
1988-02-22 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
1988 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 1988: Regenerative Phenomena in Neuro-Ophthalmology Symposium |
Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
Publisher |
North American Neuro-Ophthalmology Society |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6894cm7 |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
183479 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6894cm7 |