Pattern Electroretinogram for Detecting Retinal Neural Loss in Neuromyelitis Optica and Multiple Sclerosis Patients With or Without Optic Neuritis. Correlation With OCT and Automated Perimetry

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are related diseases that typically affect the anterior visual pathway leading to visual loss. The quantification of axonal loss in both MS and NMO has received great attention with OCT but may also be assessed by pattern electroretinography (PERG). The purpose of this study is to evaluate the ability of transient PERG parameters to differentiate between eyes of patients with NMO, longitudinally extensive transverse myelitis (LETM), MS with (MS+ON) and without optic neuritis (MS-ON) and controls, and to assess the relationship between PERG amplitude and OCT or standard automated perimetry.