Multicenter Inter-rater Reliability of Retinal Layer Segmentation Using Spectral-domain OCT

Optical coherence tomography (OCT) measures of different retinal layers correlate with structural and functional markers of disease severity in multiple sclerosis (MS), making intra-retinal layer segmentation of high-resolution OCT scans an increasingly important tool for the assessment of clinical progression in MS patients. While automatic intra-retinal layer segmentation is not yet widely available, semi-automatic segmentation of scans is necessary. The aim of our study was to evaluate reliability of semi-automatic and assisted intra-retinal layer segmentation in a multicentre setting and to identify sources of disagreement.