Identifier |
20130211_nanos_sciplatform1_01 |
Title |
Unopposed Immune Stimulation in Giant Cell Arteritis (GCA): A Consequence of a Reprogrammed STAT1 Signaling Pathway |
Creator |
Mohan, Shalini V; Liao, YJ; Yang, Bryan; Hartmann, Bjorn; Grossniklaus, Hans E; Weisman, Michael H; Goronzy, Jorg J; Weyand, Cornelia M |
Subject |
Giant Cell Arteritis; Ischemic Optic Neuropathy; STAT1; CD4+ T cells; Regulatory T cells |
Description |
GCA can manifest with severe vision loss from involvement of the ophthalmic artery or its branches. Arteritis is caused by unopposed activation of CD4+ T cells and persistent cytokine production (e.g. IL-6). In healthy immune responses, early innate cytokines (e.g. IFN-) drive feed-forward amplification loops but also promote anti-inflammatory T-regulatory cells (Treg) to contract and terminate immune reactions. We have studied whether such critical immune regulatory pathways are maintained in GCA. |
Date |
2013-02-11 |
Language |
eng |
Format |
application/pdf |
Format Creation |
application/pdf |
Type |
Text |
Source |
2013 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2013: Platform Presentations (Session I) |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s65m9cc5 |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Contributor Primary |
FitzGibbon, Edmond |
Contributor Secondary |
Lam, Byron L |
Setname |
ehsl_novel_nam |
ID |
183263 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s65m9cc5 |