A Phase I Open Label, Dose Escalation Trial Of QPI-1007 Delivered By A Single Intravitreal (IVT) Injection To Subjects With Low Visual Acuity And Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)

Update Item Information
Identifier 20130212_nanos_sciplatform2_01-1
Title A Phase I Open Label, Dose Escalation Trial Of QPI-1007 Delivered By A Single Intravitreal (IVT) Injection To Subjects With Low Visual Acuity And Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
Creator Katz, Bradley J; Antoszyk, A; Singh, RP; Gurses-Ozden, R; Erlich, S; Rothenstein, D; Sharon, N; Hodge, J; Leonard A. Levin, MD, PhD. Chair of Ophthalmology, McGill University; Miller, NR
Subject Ischemic Optic Neuropathy; Intravitreal Injection; Caspase 2; siRNA; QPI-1007
Description Subjects with stable low vision due to posterior segment pathology and subjects with acute onset NAION were enrolled in a 2 strata, Phase I, multi-center, open-label, and dose escalation study to determine safety, tolerability, and the structural and functional changes after single IVT injection of QPI-1007, a synthetic, chemically modified siRNA that inhibits expression of caspase 2.
Date 2013-02-12
Language eng
Format application/pdf
Format Creation application/PowerPoint
Type Text
Source 2013 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS 2013: Platform Presentations (Session II)
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Rights Management Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6k109xz
Context URL The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/
Contributor Primary Agarwal, Madhu
Contributor Secondary Quiros, Peter
Setname ehsl_novel_nam
ID 183229
Reference URL https://collections.lib.utah.edu/ark:/87278/s6k109xz
Back to Search Results