Identifier |
20000326_nanos_sciplatform1_02 |
Title |
Gabapentin-Lactam: A Novel Neuroprotective Agent |
Creator |
Wolf Lagrèze, MD; R. Müller-Velten; T.Feuerstein |
Affiliation |
Freiburg, Germany |
Subject |
Gabapentin-Lactam; Neuroprotective Agent; Glaucoma; Retinal Ischemia; Ganglion Cells |
Description |
In glaucoma and in retinal ischemia, excessive extracellular glutamate can damage retinal ganglion cells. Glutamate receptor antagonists as well as glutamate release inhibitors can alleviate this neuronal loss. In a pilot experiment we found that the antiglutamatergic drug Gabapentin was not neuroprotective in vivo whereas its derivative Gabapentin-Lactam was neuroprotective. We also could demonstrate that inhibition of glutamate release could be blocked with Glibenclamide indicating that Gabapentin-Lactam acts as an opener of ATP-sensitive potassium channels. |
Date |
1999-03-14 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2000 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2000: Scientific Platform Presentations (Session I) |
Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
Publisher |
North American Neuro-Ophthalmology Society |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
Copyright 2000. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s65b381d |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
182342 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s65b381d |