Opsoclonus and Ocular Flutter in Multiple Sclerosis

Opsoclonus and ocular flutter almost always occur as part of either a parainfectious or paraneoplastic syndrome. Toxic causes are also described. Most other etiologies are exemplified by single or only a few cases. The visible pathology in autopsied cases is very variable, and different pathophysiologic mechanisms have been proposed. The literature contains only one reasonably convincing case of opsoclonus, two of flutter, and one of both phenomena in the same patient, in patients with multiple sclerosis.