| Identifier |
20060227_nanos_sciplatform_06.pdf |
| Title |
Sirtuin-Activating Compounds Prevent Retinal Ganglion Cell Loss During Acute Optic Neuritis |
| Creator |
Kenneth S. Shindler; Abdolmohamad M. Rostami |
| Affiliation |
(KSS) University of Pennsylvania Scheie Eye Institute, Philadelphia, PA; (AMR) Thomas Jefferson University, Philadelphia, PA |
| Subject |
Optic Neuritis; Neuroprotection; EAE; Multiple Sclerosis; Sirtuin |
| Description |
SIRT1 is an enzyme involved in cellular stress resistance and survival. Activation of SIRT1 has been shown to prevent degradation of axotomized DRG neurons. The neuroprotective effects of SRT647, a SIRT1 activator, were examined during optic neuritis in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). |
| Date |
2006-02-27 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2006 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS 2006: Scientific Platform Presentations (Session I) |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2010. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6vq681j |
| Setname |
ehsl_novel_nam |
| ID |
181013 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6vq681j |
