Gene Mediated Therapy for LHON

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Identifier 20070212_nanos_novelnotreatmentsympos_08.pdf
Title Gene Mediated Therapy for LHON
Creator Guy, John
Subject Mitochondria; Gene therapy
Description Leber Hereditary Optic Neuropathy (LHON) is a maternally inherited disorder that results in loss of vision during the 2nd and 3rd decades of life. The G to A transition at nucleotide 11778 in mitochondrial DNA (mtDNA) in the gene specifying the NADH dehydrogenase subunit 4 (ND4) of complex I causes half the cases.1,2 It results in an arginine to histidine substitution at amino acid 340. 3 Still approximately 45 other pathogenic point mutations in human polypeptide-coding mtDNA genes have been linked to LHON.4 Of all diseases caused by mutated mitochondria LHON is the most common.
Language eng
Format application/pdf
Format Creation application/pdf
Type Text
Source 2007 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS 2007: Novel Approaches to Treatment of Neuro-Ophthalmic Diseases: Part II: Neuroprotection and Other Methods for Salvaging Visual Function
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Rights Management Copyright 2010. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s60037jq
Context URL The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/
Setname ehsl_novel_nam
ID 180927
Reference URL https://collections.lib.utah.edu/ark:/87278/s60037jq
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