Identifier |
20070212_nanos_novelnotreatmentsympos_05.pdf |
Title |
Viral Mediated Therapy for Photoreceptor Disease |
Creator |
William Hauswirth; Seok-Hong Min; John Alexander |
Affiliation |
University of Florida, Gainesville, FL |
Subject |
AAV Vectors; Gene Replacement Therapy; AAV Serotype; X-linked Retinoschisis; Achromatopsia |
Description |
The mammalian retina is an ideally suited target organ for developing gene-based therapies for several key reasons. First, the cell types primarily affected in known retinal diseases, retinal ganglion cells on the inner face of the retina, photoreceptors on its outer surface and retinal pigmented epithelial cells adjacent to and interdigitated with photoreceptors, are all readily accessible to the skilled surgeon.Second, there is perhaps a deeper appreciation of the range of genetic diseases of the retina than for any other organ, viz. there are currently about 150 known genetic retinal disease loci in the human genome, of which approximately 90 are known at the complete sequence level.Third, noninvasive assessment of retinal function and structure has been the focus of clinical ophthalmology for more than a century. |
Date |
2007-02-12 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2007 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2007: Novel Approaches to Treatment of Neuro-Ophthalmic Diseases: Part II: Neuroprotection and Other Methods for Salvaging Visual Function |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2010. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6c56s64 |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
180924 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6c56s64 |