| Identifier |
walsh_2000_s1_c2 |
| Title |
I Forgot. Why Did You Say I Had Double Vision? |
| Creator |
Daniel M. Jacobson, MD (1956-2003) |
| Subject |
CADASIL; Brain Ischemia; Diplopia; Ophthalmoplegia; Chromosome Disorders |
| History |
A 50-year old female with painless binocular double vision who later developed seizures and impaired memory and language function. |
| Pathology |
Strokes with ischemic encephalopathy |
| Disease/Diagnosis |
Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy |
| Clinical |
Left-sided internuclear ophthalmoplegia; 21/30 mini-mental status test |
| Presenting Symptom |
Binocular diplopia; Seizures; Memory and language deficits |
| Neuroimaging |
MRI |
| Treatment |
N/A |
| References |
1. Davoyus P. CADASIL: a review with proposed diagnostic criteria. Eur J Neurol 1998;5:219-33. 2. Ruchoux MM, Maurage CA. CADASIL: Cerebral autosomal dominant ateriopathy with subcortical infarcts and leukoen-cephalopathy. J Neuropathol Exp Neurol 1997;56:947-64. 3. Dichgans M, Mayer M, Uttner I et al. The phenotypic spectrum of CADASIL: Clinical findings in 102 cases. Ann Neurol 1998;44:731-9. 4. Joutel A, Vahedi K, Corpechot C et al. Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients. Lancet 1997;350:1511-5. 5. Chabriat H, Vahedi K, Iba-Zizen MT et al. Clinical spectrum of CADASIL: A study of 7 families. Lancet 1995;346:934-9. 6. Chabriat H, Levy C, Taillia H et al. Patterns of MRI lesions in CADASIL. Neurology 1988;51:452-7. 7. Chabriat H, Mrissa R, Levy C et al. Brain stem MRI signal abnormalities in CADASIL. Stroke 1999;30:457-9. 8. Ruchoux MM, Guerouaou D, Vandenhaute B et al. Systemic vascular smooth muscle cell impairmen in cerebral autoso-mal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Acta Neuropathol 1995;89:500-12. 9. Ebke M, Dichgans M, Bergmann M et al. CADASIL: Skin biopsy allows diagnosis in early stages. Acta Neurol Scan 1997;95:351-7. 10. Mayer M, Straube A, Bruening R et al. Muscle and skin biopsies are a sensitive diagnostic tool in the diagnosis of CADASIL. J Neurol 1999;246:526-32. |
| Language |
eng |
| Format |
application/pdf |
| Relation is Part of |
Case presented at the NANOS 2000 Walsh Session, March 25-26. |
| Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Rights Management |
Copyright 2008. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6sf2zz1 |
| Contributor Primary |
Jacobson, Daniel M. |
| Contributor Secondary |
Karanjia, Percy N.; Riepe, Roger E. |
| Setname |
ehsl_novel_fbw |
| ID |
178130 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6sf2zz1 |
