Electroretinography (ERG) Monitoring for Vigabatrin Visual Toxicity (The Cons)

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Identifier 20210223_nanos_controversiespediatricno1_01-slidesb
Title Electroretinography (ERG) Monitoring for Vigabatrin Visual Toxicity (The Cons)
Creator Michael J. Wan, MD, FRCSC
Subject Vigabatrin; Toxicity; Vision Loss; Electroretinography (ERG); Epilepsy
Description Vigabatrin is a known cause of ocular toxicity and visual field loss. Early reports estimated ocular toxicity at 52% in adults and 34% in children. However, most early data was from small, retrospective studies and, crucially, many patients did not have baseline visual testing and had been on long-term treatment with vigabatrin. Due to the reports of ocular toxicity, the Food and Drug Administration (FDA) started a mandatory drug registry for vigabatrin with robust visual function testing. From 2009 to 2016, 1,509 patients had ophthalmic testing and only 2% had a potential vigabatrin-associated effect on vision. Furthermore, many of the cases of potential toxicity returned to normal on repeat testing. Interestingly, 37% of the cohort did have pre-existing pathology affecting the visual system, which might have been interpreted as toxicity had baseline testing not been done.
Relation is Part of NANOS Annual Meeting 2021: Controversies in Pediatric Neuro-Ophthalmology
Contributor Primary Michael J. Wan, MD, FRCSC
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2021-02
Type Text
Format application/pdf
Source 2021 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management Copyright 2021. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Language eng
ARK ark:/87278/s64v2h7g
Setname ehsl_novel_nam
Date Created 2021-04-29
Date Modified 2021-05-06
ID 1694058
Reference URL https://collections.lib.utah.edu/ark:/87278/s64v2h7g
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