Identifier |
20210220_nanos_posters_027 |
Title |
Optic Neuritis With Glial Fibrillary Acid Protein Antibodies in the Setting of Nivolumab Use |
Creator |
Loulwah Mukharesh; John Chen; Eoin Flanagan; Marc Bouffard |
Affiliation |
(LM) Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA; (JC) (EF) Mayo Clinic, Rochester, MN; (MB) Beth Israel Deaconess Medical Center, Boston, MA |
Subject |
Optic Neuritis; Neuro-ophthalmology & Systemic Disease (eg. MS, MG, Thyroid); Miscellaneous |
Description |
Immune-checkpoint inhibitors(ICIs) have revolutionized cancer treatment by modulating/disinhibiting the immune system leading to infrequent immune-related adverse events (irAEs).1,2 Nivolumab is a PD-1 blocking-antibody immune-checkpoint inhibitor used to treat malignant melanoma, non-small cell lung cancer, and renal cell carcinoma. Glial fibrillary acidic protein(GFAP) is an astrocytic cytoplasmic intermediate-filament protein. GFAP-IgG meningoencephalomyelitis is a steroid-responsive autoimmune condition and sometimes paraneoplastic-related3,4 There have been rare reports of GFAP-IgG autoimmune meningoencephalitis after checkpointinhibitors, 5,6 but none with vision loss as the main finding. |
Date |
2021-02 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2021 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2021: Poster Session I: Neuro-Ophthalmic Disorders of Neurologic and Systemic Diseases |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2021. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6jb22k4 |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
1671514 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6jb22k4 |