Toxic Optic Neuropathy From Quinine Overdose

Update Item Information
Title Toxic Optic Neuropathy From Quinine Overdose
Creator Paul R. Freund; Tom Wright; Edward A. Margolin
Affiliation Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada
Abstract A 45-year-old man presented with longstanding poor vision in both eyes. His medical history was significant for a remote overdose of quinine. After the ingestion, he fell into a coma and on awakening was not able to see light out of both eyes. Several days later, his central vision began to gradually recover and continued to improve over the span of several months. Presently, he had 20/20 visual acuity in both eyes with severely constricted peripheral visual fields. There were bilateral iris transillumination defects, and both optic nerves were diffusely pale with attenuated vasculature and inner retinal thinning on ocular coherence tomography. We present a patient with the stereotypical findings and natural history of quinine toxicity, a rare and not widely known cause of toxic optic neuropathy and retinopathy.
Subject Analgesics, Non-Narcotic / poisoning; Drug Overdose / complications; Drug Overdose / diagnosis; Humans; Male; Middle Aged; Optic Nerve / drug effects; Optic Nerve / pathology; Quinine / poisoning; Tomography, Optical Coherence / methods; Toxic Optic Neuropathy / diagnosis; Toxic Optic Neuropathy / etiology; Visual Acuity; Visual Fields
Date 2020-06
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, June 2020, Volume 40, Issue 2
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s60p6pfs
Setname ehsl_novel_jno
ID 1592950
Reference URL https://collections.lib.utah.edu/ark:/87278/s60p6pfs
Back to Search Results