(SG) (LW) (MK) (YH) (VA) Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; (AT) Department of Ophthalmology & Visual Sciences, University of Michigan, Ann Arbor, Michigan
Subject
Optic Neuropathy; Genetic Disease
Description
Optic atrophy resulting from retinal ganglion cell (RGC) degeneration is the most prominent ocular manifestation of mitochondrial dysfunction. Efforts to develop effective pharmacotherapies for mitochondrial optic neuropathies have been hampered, in part, by the lack of an ideal preclinical animal model. Although mutant mice lacking the mitochondrial complex I accessory subunit NADH:ubiquinone oxidoreductase (NDUFS4) develop early-onset optic atrophy, severe systemic mitochondrial dysfunction leads to very early death, making this mouse line impractical for studying the pathobiology of mitochondrial optic neuropathy.
Date
2020-03
Language
eng
Format
video/mp4
Type
Image/MovingImage
Source
2020 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of
NANOS Annual Meeting 2020: Scientific Platform Session III