Progressive Optic Atrophy in a Retinal Ganglion Cell-Specific Mouse Model of Complex I Deficiency (Video)

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Identifier 20200310_nanos_sciplatform3_03
Title Progressive Optic Atrophy in a Retinal Ganglion Cell-Specific Mouse Model of Complex I Deficiency (Video)
Creator Sidney M. Gospe, III, Luyu Wang, Mikael Klingeborn, Amanda Travis, Ying Hao, Vadim Arshavsky
Subject Optic Neuropathy, Genetic Disease
Description Optic atrophy resulting from retinal ganglion cell (RGC) degeneration is the most prominent ocular manifestation of mitochondrial dysfunction. Efforts to develop effective pharmacotherapies for mitochondrial optic neuropathies have been hampered, in part, by the lack of an ideal preclinical animal model. Although mutant mice lacking the mitochondrial complex I accessory subunit NADH:ubiquinone oxidoreductase (NDUFS4) develop early-onset optic atrophy, severe systemic mitochondrial dysfunction leads to very early death, making this mouse line impractical for studying the pathobiology of mitochondrial optic neuropathy.
Relation is Part of NANOS Annual Meeting 2020: Scientific Platform Session III
Contributor Primary Sidney M. Gospe, III, MD, PhD
Contributor Secondary Luyu Wang, Mikael Klingeborn, Amanda Travis, Ying Hao, Vadim Arshavsky
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2020-03
Format video/mp4
Source 2020 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management Copyright 2020. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Language eng
ARK ark:/87278/s6vx5t29
Setname ehsl_novel_nam
Date Created 2020-04-29
Date Modified 2020-05-20
ID 1544739
Reference URL https://collections.lib.utah.edu/ark:/87278/s6vx5t29
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