Identifier |
20200310_nanos_sciplatform3_03-pdf |
Title |
Progressive Optic Atrophy in a Retinal Ganglion Cell-Specific Mouse Model of Complex I Deficiency (PDF) |
Creator |
Sidney Gospe, III; Luyu Wang; Mikael Klingeborn; Amanda Travis; Ying Hao; Vadim Arshavsky |
Affiliation |
(SG) (LW) (MK) (YH) (VA) Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; (AT) Department of Ophthalmology & Visual Sciences, University of Michigan, Ann Arbor, Michigan |
Subject |
Optic Neuropathy; Genetic Disease |
Description |
Optic atrophy resulting from retinal ganglion cell (RGC) degeneration is the most prominent ocular manifestation of mitochondrial dysfunction. Efforts to develop effective pharmacotherapies for mitochondrial optic neuropathies have been hampered, in part, by the lack of an ideal preclinical animal model. Although mutant mice lacking the mitochondrial complex I accessory subunit NADH:ubiquinone oxidoreductase (NDUFS4) develop early-onset optic atrophy, severe systemic mitochondrial dysfunction leads to very early death, making this mouse line impractical for studying the pathobiology of mitochondrial optic neuropathy. |
Date |
2020-03 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2020 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2020: Scientific Platform Session III |
Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
Publisher |
North American Neuro-Ophthalmology Society |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
Copyright 2020. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6kx0rqm |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
1543309 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6kx0rqm |