Retinal Imaging in Neurodegenerative Diseases of Brain

Recent research suggests that Tau is the culprit lesion along with neuroinflammation in the etiology of Alzheimer' s Disease ( AD ). Retina is the extention of the brain and is the most easily approachable part of the central nervous system. Detection of the pathological protein accumulations may be possible by using spectral domain optical coherescent tomography ( SD-OCT ) and fundus autofluorescein ( FAF ). There is evidence showing that retinal plaques start accumulating even earlier than the ones in the brain. Most recent Tau protein images in the brain consist of normal or reverse C-shaped paired hellical filaments.