Role for OCT in Detecting Homonymous Ganglion Cell Layer Thinning in Patients with Demyelinating Disease

Thinning in the ganglion cell layer + the inner plexiform layer (GCIPL) on optical coherence tomography (OCT) can be quantified and used as a proxy for neurodegeneration. Additionally, studies have demonstrated that lesions in the optic radiations can lead to a characteristic homonymous pattern of degeneration in the retina. It is unknown whether lesions in demyelinating diseases including multiple sclerosis (MS), neuro-myelitis optica (NMO) and anti- myelin oligodendrocyte glycoprotein syndrome (anti-MOG) lead to these patterns on OCT. This study's purpose was to identify homonymous patterns of GCIPL thinning in a demyelinating diseasecohort.