Critical Flicker Fusion as a Novel Measure of Remyelination in Multiple Sclerosis

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Identifier 20200310_nanos_posters_231
Title Critical Flicker Fusion as a Novel Measure of Remyelination in Multiple Sclerosis
Creator Kathleen Shangraw, Kimberly Winges, Rebecca Spain, Elizabeth Silbermann
Subject Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid), Diagnostic Tests (ERG, VER, OCT, HRT, mfERG, etc), Eyelid & Adnexal Disease, Demeylinating Disease, Visual Field
Description Visual dysfunction is ubiquitous in multiple sclerosis (MS). Demyelination of the optic nerve is common, and visual impairment is a leading cause of disability in people with MS (pwMS). The eye provides an easily accessible window into the central nervous system, making the visual system an ideal model to evaluate remyelination therapies in MS. However, there are currently no fast, validated tests which reliably measure myelination status in the visual pathway. Visual evoked potential (VEP) is the current gold-standard measure of optic nerve function, however it is resource and time intensive, limiting its use. Critical flicker fusion (CFF) is a low-cost, efficient measure of optic nerve function. Participants view a rapidly flashing light that increases in frequency until it is perceived as a continuous light, the CFF threshold. While prior studies have demonstrated altered CFF thresholds in pwMS after optic neuritis, this is the first to establish intra-subject reliability and efficacy of CFF in pwMS with stable disease in comparison to VEP.
Relation is Part of NANOS Annual Meeting 2020: Poster Session II: Scientific Advancements
Contributor Primary Kathleen Shangraw
Contributor Secondary Kimberly Winges, Rebecca Spain, Elizabeth Silbermann
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2020-03
Format application/pdf
Source 2020 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management Copyright 2020. For further information regarding the rights to this collection, please visit:
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-ophthalmology Virtual Education Library: NOVEL
Language eng
ARK ark:/87278/s6m09fx0
Setname ehsl_novel_nam
Date Created 2020-04-21
Date Modified 2020-05-26
ID 1542099
Reference URL
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