Identifier |
20200309_nanos_sciplatform1_04 |
Title |
Teprotumumab Effect on Proptosis, Diplopia and Quality of Life in Active Thyroid Eye Disease (TED) (Video) |
Creator |
Jade Schiffman, Rosa Tang, George Kahaly, Terry Smith, Saba Sile, Elizabeth Thompson, Thomas Vescio, Jeffrey Sherman, Raymond Douglas |
Subject |
Graves (Systemic Disease), Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid), Optic Neuropathy, Adult Strabismus with a Focus on Diplopia, Orbit/Ocular Pathology |
Description |
Active thyroid eye disease (TED), a progressive, autoimmune condition, produces retro-orbital inflammation/tissue expansion. Patients present with ocular pain, redness, and swelling. Retro-orbital fat/muscle expansion produces subsequent proptosis, diplopia, and strabismus. These manifestations can persist after inflammation is no longer evident. A phase 3 placebo-controlled trial recently confirmed that teprotumumab, an IGF-1R inhibitory antibody, significantly reduced TED-associated proptosis and improved other outcomes.[1] Key TED outcomes (proptosis [mm], subjective Bahn/Gorman diplopia grade, and GO-QOL) from the teprotumumab phase 2 and 3 trials are reported here.[1,2] |
Date |
2020-03 |
Language |
eng |
Format |
video/mp4 |
Source |
2020 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2020: Scientific Platform Session I |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2020. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6kt21kv |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Contributor Primary |
Jade Schiffman, MD |
Contributor Secondary |
Rosa Tang, George Kahaly, Terry Smith, Saba Sile, Elizabeth Thompson, Thomas Vescio, Jeffrey Sherman, Raymond Douglas |
Setname |
ehsl_novel_nam |
ID |
1541919 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6kt21kv |