Teprotumumab Effect on Proptosis, Diplopia and Quality of Life in Active Thyroid Eye Disease (TED) (Video)

Update item information
Identifier 20200309_nanos_sciplatform1_04
Title Teprotumumab Effect on Proptosis, Diplopia and Quality of Life in Active Thyroid Eye Disease (TED) (Video)
Creator Jade Schiffman, Rosa Tang, George Kahaly, Terry Smith, Saba Sile, Elizabeth Thompson, Thomas Vescio, Jeffrey Sherman, Raymond Douglas
Subject Graves (Systemic Disease), Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid), Optic Neuropathy, Adult Strabismus with a Focus on Diplopia, Orbit/Ocular Pathology
Description Active thyroid eye disease (TED), a progressive, autoimmune condition, produces retro-orbital inflammation/tissue expansion. Patients present with ocular pain, redness, and swelling. Retro-orbital fat/muscle expansion produces subsequent proptosis, diplopia, and strabismus. These manifestations can persist after inflammation is no longer evident. A phase 3 placebo-controlled trial recently confirmed that teprotumumab, an IGF-1R inhibitory antibody, significantly reduced TED-associated proptosis and improved other outcomes.[1] Key TED outcomes (proptosis [mm], subjective Bahn/Gorman diplopia grade, and GO-QOL) from the teprotumumab phase 2 and 3 trials are reported here.[1,2]
Relation is Part of NANOS Annual Meeting 2020: Scientific Platform Session I
Contributor Primary Jade Schiffman, MD
Contributor Secondary Rosa Tang, George Kahaly, Terry Smith, Saba Sile, Elizabeth Thompson, Thomas Vescio, Jeffrey Sherman, Raymond Douglas
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2020-03
Format video/mp4
Source 2020 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management Copyright 2020. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Language eng
ARK ark:/87278/s6kt21kv
Setname ehsl_novel_nam
Date Created 2020-04-20
Date Modified 2020-05-19
ID 1541919
Reference URL https://collections.lib.utah.edu/ark:/87278/s6kt21kv