Visual Evoked Potentials as a Biomarker in Multiple Sclerosis and Associated Optic Neuritis

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Title Visual Evoked Potentials as a Biomarker in Multiple Sclerosis and Associated Optic Neuritis
Creator Letizia Leocani, MD; Simone Guerrieri, MD; Giancarlo Comi, MD
Affiliation Department of Neurology, Institute of Experimental Neurology-INSPE, San Raffaele University Hospital, Milan, Italy
Abstract Multiple sclerosis (MS) is an inflammatory, degenerative disease of the central nervous system (CNS) characterized by progressive neurological decline over time. The need for better 'biomarkers' to more precisely capture and track the effects of demyelination, remyelination, and associated neuroaxonal injury is a well-recognized challenge in the field of MS. To this end, visual evoked potentials (VEPs) have a role in assessing the extent of demyelination along the optic nerve, as a functionally eloquent CNS region. Moreover, VEPs testing can be used to predict the extent of recovery after optic neuritis (ON) and capture disabling effects of clinical and subclinical demyelination events in the afferent visual pathway. In this review, the evolving role of VEPs in the diagnosis of patients with ON and MS and the utility of VEPs testing in determining therapeutic benefits of emerging MS treatments is discussed.
Subject Evoked Potentials, Visual; Humans; Multiple Sclerosis / complications; Multiple Sclerosis / physiopathology; Optic Nerve / physiopathology; Optic Neuritis / etiology; Optic Neuritis / physiopathology
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Date 2018-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, September 2018, Volume 38, Issue 3
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s62v7h2h
Setname ehsl_novel_jno
ID 1500817
Reference URL https://collections.lib.utah.edu/ark:/87278/s62v7h2h
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