Intravitreal Triamcinolone Acetonide Injection in a Rodent Model of Anterior Ischemic Optic Neuropathy

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Title Intravitreal Triamcinolone Acetonide Injection in a Rodent Model of Anterior Ischemic Optic Neuropathy
Creator Luciano S. Perira, MD, PhD, Marcos P. Ávila, MD, PhD, Luciana X. Salustiano, MD, PhD, Alcio C. Paula, MD, PhD, Emmanuel Arnhold, PhD, Timothy J. McCulley, MD
Affiliation Departments of Ophthalmology (LSP, MPA, ACP), Pathology (LXS), and Statistics (EA), Universidade Federal de Goiás, Goiânia, Brazil; and The Wilmer Eye Institute (TJM), Johns Hopkins University, Baltimore, Maryland
Abstract The management of nonarteritic anterior ischemic optic neuropathy centers around prevention of second eye involvement, without a uniformly accepted therapy for the involved eye. Several researchers have assessed the benefit of steroids with conflicting results. This experimental study was designed to evaluate the efficacy of a single intravitreal triamcinolone acetonide injection (IVTA) in preserving retinal ganglion cells (RGCs) in a rodent model of anterior ischemic optic neuropathy (rAION). The rAION was induced in female Wistar rats. Animals were randomized into 3 groups: 1) untreated, 2) treated with 56 μg IVTA, and 3) intravitreal saline (placebo). Procedures were performed in the left eye, with the right eye serving as control. After 30 days, animals were sacrificed and eyes were assessed histologically for RGC number. The average number of RGC was significantly lower in rAION subgroups when compared with the control group (P < 0.001). No significant difference was seen between rAION eyes treated with IVTA, placebo, and untreated eyes (P > 0.05%). In this rodent model for AION, no therapeutic benefit of intravitreal steroid injection was identified.
OCR Text Show
Publisher Lippincott, Williams & Wilkins
Date 2018-12
Type Text
Source Journal of Neuro-Ophthalmology, December 2018, Volume 38, Issue 4
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s68q11fv
Setname ehsl_novel_jno
Date Created 2020-01-08
Date Modified 2020-03-10
ID 1500769
Reference URL
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