Physiologic Electrical Fields Direct Retina Ganglion Cell Axon Growth

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Identifier 20190319_nanos_sciplatform3_07_slides
Title Physiologic Electrical Fields Direct Retina Ganglion Cell Axon Growth
Creator Kimberly Gokoffski, Xingyuan Jia, Guohua Xia, Min Zhao
Subject Optic Neuropathy, Miscellaneous
Description Cell transplantation-based approaches to restore vision in patients blinded by advanced optic neuropathies show immense promise but are limited by 1) low integration efficiency and 2) of the RGCs that integrated, few axons grew out of the eye. What these experiments demonstrate is that the endogenous cues in the host retina and optic nerve are insufficient to direct the growth of newly transplanted RGC axons out of the eye. There is much interest in the potential of electrical fields (EFs) to promote long distance axon growth: axons of hippocampal neurons have grow directionally when exposed to an EF. Drawing from this, we hypothesized that EFs might exert a similar galvanotropic effect on RGC axon growth. If so, can EFs be exploited to direct RGC axon growth out of the eye.
Relation is Part of NANOS 2019: Scientific Platform III
Contributor Primary Kimberly Gokoffski
Contributor Secondary Xingyuan Jia, Guohua Xia, Min Zhao
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2019-03
Format application/pdf
Source 2019 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management Copyright 2019. For further information regarding the rights to this collection, please visit:
Collection Neuro-ophthalmology Virtual Education Library: NOVEL
Language eng
ARK ark:/87278/s63z2tg2
Setname ehsl_novel_nam
Date Created 2019-09-10
Date Modified 2019-09-10
ID 1455039
Reference URL
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