Identifier |
20190319_nanos_sciplatform3_05_slides |
Title |
Melanopsin: Targeted Ectopic Expression for Optogenetic Visual Restoration |
Creator |
Michael Gilhooley; Moritz Lindner; Steven Hughes; Mark Hankins |
Affiliation |
(MG) University of Oxford & Moorfields Eye Hospital, Oxford, United Kingdom of Great Britain and Northern Ireland; (ML) Institute of Physiology and Pathophysiology, Philipps University, Marburg, Germany; (SH) (MH) University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland |
Subject |
Genetic Disease; Pupils Retina; Optic Nerve Trauma and Treatment |
Description |
Expression of melanopsin renders neural cells sensitive to light, and is emerging as a prime candidate for clinical optogenetic approaches to visual restoration. The retinal neural tissue surviving in the inherited retinal degenerations (IRDs) after visual loss presents a model target for such approaches, however it is unclear if targeting specific neuronal populations within this tissue is advantageous over non-specific delivery. A fair comparison between these two methods is made difficult by the persistence of native photosensitive retinal ganglion cell (pRGC) responses in IRD models. Here we describe a novel model lacking all native retinal light responses to allow a more robust comparison of optogenetic targets. The purpose of our study is to test the hypothesis that retinae devoid of both canonical and pRGC photoreception will remove the 'noise' of intrinsic responses and allow comparison of targeted expression of melanopsin in ON-bipolar cells with non-specific delivery. |
Date |
2019-03 |
Language |
eng |
Format |
application/pdf |
Format Creation |
Microsoft PowerPoint |
Type |
Text |
Source |
2019 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2019: Scientific Platform III |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2019. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6cg49zj |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
1455037 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6cg49zj |