MEK Inhibitor Treatment Promotes Retinal Ganglion Cell Preservation without Preventing Retrobulbar Demyelination in Neurofibromatosis Mice

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Identifier 20190319_nanos_sciplatform3_04_slides
Title MEK Inhibitor Treatment Promotes Retinal Ganglion Cell Preservation without Preventing Retrobulbar Demyelination in Neurofibromatosis Mice
Creator Steven Stasheff, Francisco Nadal-Nicolas, Wei Li, Miriam Bornhorst, Yuan Zhu
Subject Pediatric Neuro-Ophthalmology, Neuro-Ophth & Systyemic Disease (eg. MS, MG, Thyroid), Genetic; Disease, Chemotherapy and Radiation Injury, Higher Visual Functions
Description To better understand the disparity frequently seen between optic pathway glioma (OPG) characteristics and visual loss among young children with neurofibromatosis type 1 (NF1), we extend our previous findings of anatomic, physiologic, and behavioral abnormalities in an established animal model. We now report differential effects of treatment targeting the MAPK/ERK cellular pathway: 1) preserving retinal ganglion cell (RGC) number, and yet 2) failing to ameliorate demyelination of the retrobulbar optic nerve.
Relation is Part of NANOS 2019: Scientific Platform III
Contributor Primary Steven Stasheff
Contributor Secondary Francisco Nadal-Nicolas, Wei Li, Miriam Bornhorst, Yuan Zhu
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2019-03
Format application/pdf
Source 2019 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management Copyright 2019. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Language eng
ARK ark:/87278/s6h752mc
Setname ehsl_novel_nam
Date Created 2019-09-10
Date Modified 2019-09-10
ID 1455036
Reference URL https://collections.lib.utah.edu/ark:/87278/s6h752mc
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