mTOR Inhibitor Causes Regression of Retinal Hamartomas in Patients with Tuberosclerosis

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Identifier 20190317_nanos_posters_126
Title mTOR Inhibitor Causes Regression of Retinal Hamartomas in Patients with Tuberosclerosis
Creator Nitza Goldenberg-Cohen; Karin Herscu; Roni Cohen; Inbal Man-Peles; Shalom Michowitz
Affiliation (NGC) Ophthalmology, Bnai Zion Medical Center, Haifa; Faculty of Medicine, Technion, Haifa, Israel; (KH) (IMP) Ophthalmology, Bnai Zion Medical Center, Haifa, Israel; (RC) Neurology, Schneider Children's Medical Center, Petach Tikva, Israel; (SM) Neurosurgery, Schneider Children's Medical Center, Petach Tikva, Israel
Subject Diagnostic Tests (ERG, VER, OCT, HRT, mfERG, etc); Eyelid & Adnexal Disease; Genetic Disease
Description Tuberous sclerosis (TS) is a systemic disorder characterized by hamartomas in multiple organs (1), among those the retina. The mutations underlying TS are TSC1 or TSC2, resulting in activation of mTOR which promotes cell proliferation (1). Everolimus, mTOR inhibitor, is a new treatment for TS-related lesions, indicated for the treatment of subependymal giant cell astrocytomas (SEGA) in the brain and renal angiomyolipomas (2). Here we present regress in the size of the retinal hamartomas in a TS patient following systemic treatment with Everolimus.
Date 2019-03
Language eng
Format application/pdf
Type Text
Source 2019 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NAM 2019: Poster Session I: Clinical Highlights in Neuro-Ophthalmology
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Rights Management Copyright 2019. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6vj06c6
Context URL The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/
Setname ehsl_novel_nam
ID 1432607
Reference URL https://collections.lib.utah.edu/ark:/87278/s6vj06c6
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