Optic Nerve: A window to Neurosyphilis

Syphilis is a multisystem chronic infection caused by Treponema Pallidum that progresses into four stages if untreated. Primary syphilis: typical painless syphilitic ulcer (chancre at the inoculation region) (incubation period lasting for 2-3 weeks). Secondary syphilis: weeks or months later in nearly 25% of untreated patients, lymphadenopathy, gastrointestinal abnormalities and CNS alterations. Tertiary syphilis: 1-30 years after primary infection - end of latent period - (25% of untreated) progresses slowly as neurosyphilis or gummatous syphilis.