Identifier |
20190317_nanos_posters_069 |
Title |
LHON-MS patient with long-term non-response to Idebenone shows improvement after 4-AP Usage |
Creator |
William Sultan; Rustum Karanjia; Alfredo Sadun |
Affiliation |
(WS) (RK) (AS) Doheny Eye Center UCLA, Pasadena, California |
Subject |
Genetic Disease; Demeylinating Disease; Neuro-Ophth & Systyemic Disease (eg. MS, MG, Thyroid) |
Description |
Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder with a poor visual prognosis due to the loss of retinal ganglion cells and degeneration of the optic nerve head. There are 3 primary mutations: m.11778A>G, m.3460A>G, and m.14484T>C(ordered from worst to best prognosis). VA is primarily affected with a concordant decrease in central vision. Multiple sclerosis is a multisystem immune-mediated process in which an abnormal response of the body's immune system is directed toward the central nervous system. Although there is no direct connection between LHON and MS, if they cooccur there may be utility in the use of adjunctive therapy. |
Date |
2019-03 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2019 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NAM 2019: Poster Session I: Clinical Highlights in Neuro-Ophthalmology |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2019. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s68d4dpk |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
1432255 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s68d4dpk |