Identifier |
20190319_nanos_sciplatform3_07-video |
Title |
Physiologic Electrical Fields Direct Retina Ganglion Cell Axon Growth |
Creator |
Kimberly Gokoffski; Xingyuan Jia; Guohua Xia; Min Zhao |
Affiliation |
(KG) USC Roski Eye Institute, Los Angeles, California; (XJ) Medical Research Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; (GX) Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, California; (MZ) Department of Ophthalmology and Vision Sciences, University of California, Davis, Sacramento |
Subject |
Optic Neuropathy; Miscellaneous |
Description |
Cell transplantation-based approaches to restore vision in patients blinded by advanced optic neuropathies show immense promise but are limited by 1) low integration efficiency and 2) of the RGCs that integrated, few axons grew out of the eye. What these experiments demonstrate is that the endogenous cues in the host retina and optic nerve are insufficient to direct the growth of newly transplanted RGC axons out of the eye. There is much interest in the potential of electrical fields (EFs) to promote long distance axon growth: axons of hippocampal neurons have grow directionally when exposed to an EF. Drawing from this, we hypothesized that EFs might exert a similar galvanotropic effect on RGC axon growth. If so, can EFs be exploited to direct RGC axon growth out of the eye. |
Date |
2019-03 |
Language |
eng |
Format |
video/mp4 |
Type |
Image/MovingImage |
Source |
2019 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2019: Scientific Platform III |
Collection |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2019. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6wm5wr9 |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
1427564 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6wm5wr9 |