MOG-IgG Optic Neuritis

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Identifier 20190318_nanos_hottopic1_03
Title MOG-IgG Optic Neuritis
Creator John Chen, MD, PhD
Subject Myelin Oligodendrocyte Glycoprotein (MOG)-IgG; Optic Neuritis; Chronic Relapsing Inflammatory Optic Neuropathy; Neuromyelitis Optica Spectrum Disorder (NMOSD); Demyelinating Disease
Description Optic neuritis is the most common cause of optic neuropathy in young patients, which can cause debilitating vision loss and blindness. Two novel glial autoantibodies have been discovered that better characterize a subset of patients with optic neuritis. In 2004, antibodies against an astrocytic water channel, aquaporin-4 (AQP4) were discovered, which greatly improved our understanding and detection of the clinical entity neuromyelitis optica spectrum disorders (NMOSD). More recently, antibodies specific for myelin oligodendrocyte glycoprotein (MOG-IgG), have been found in a subset of patients with optic neuritis and other demyelinating phenotypes. Although initially erroneously associated with multiple sclerosis in early literature with use of solid-phase assays, newer live transfected cell-based assays have shown MOG-IgG to be a reproducible marker for a subset of patients with optic neuritis, AQP4-IgG seronegative inflammatory CNS demyelinating disorders with NMOSD-like phenotype, and acute disseminated encephalomyelitis (ADEM).
Relation is Part of NANOS Annual Meeting 2019: Hot Topics: How Do I Treat?
Contributor Primary John Chen, MD, PhD
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2019-03
Format video/mp4
Source 2019 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management Copyright 2019. For further information regarding the rights to this collection, please visit:
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-ophthalmology Virtual Education Library: NOVEL
Language eng
ARK ark:/87278/s60g81g2
Setname ehsl_novel_nam
Date Created 2019-05-10
Date Modified 2019-07-01
ID 1426196
Reference URL
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