An Epidemiological Study of LHON Using a Large International Sample of Affected Individuals
Creator
Alexander L. Pearson, BA
Subject
Optic Neuropathy, Genetic Disease
Description
Leber's hereditary optic neuropathy (LHON) is the most common inherited mitochondrial disease. It results in acute/subacute, painless, profound loss of central and color vision. The current literature reports males as 4-5 times more likely than females to be affected by LHON, and that symptom onset occurs during late teen/young; adult life. As a result, LHON is usually called a "young man's disease." However, this may be a self-fulfilling; prophecy, with underdiagnosis of females, older adults and children. We analyzed the epidemiology of LHON using a large international database of people affected by LHON.
Date
2019-03
Language
eng
Format
video/mp4
Source
2019 North American Neuro-Ophthalmology Society Annual Meeting