New Insights in Vanishing White Matter Disease: Isolated Bilateral Optic Neuropathy in Adult Onset Disease

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Title New Insights in Vanishing White Matter Disease: Isolated Bilateral Optic Neuropathy in Adult Onset Disease
Creator Sandra R. Barros; Sónia C. R. Parreira; Ana F. B. Miranda; Ana M. B. Pereira; Nuno M. P. Campos
Affiliation Ophthalmology Department (SRB, SP, AFBM, AMP, NC), Garcia de Orta Hospital, Almada, Portugal.
Subject Vanishing White Matter Disease; Isolated Bilateral Optic Neuropathy; Adult Onset Disease
Abstract Vanishing white matter disease (VWMD) is a rare disease affecting cerebral white matter. The adult form is even rarer and manifests with motor symptoms, behavioral problems, and dementia. There is no treatment and progression is inevitable. We describe a case with atypical manifestations and an unusual course. Description of a 42-year-old man with VWMD complaining of progressive visual loss in the right eye. The patient's visual acuity was 20/60, right eye, and 20/25, left eye, with pale optic nerves bilaterally. MRI showed atrophy of the corpus callosum, diffuse rarefaction of cerebral white matter including the anterior and posterior visual pathways. Our patient had no further symptoms besides loss of visual acuity, which is rare in patients with VWMD of the same age and genetic mutation.
OCR Text Show
Publisher Lippincott, Williams & Wilkins
Date 2018-03
Type Text
Source Journal of Neuro-Ophthalmology, December 2018, Volume 38, Issue 1
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s6kw9v7n
Setname ehsl_novel_jno
Date Created 2019-03-11
Date Modified 2019-03-11
ID 1404064
Reference URL https://collections.lib.utah.edu/ark:/87278/s6kw9v7n
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