Optic Nerve Deformity as a Possible Contributor to Optic Neuropathy
Joseph Demer, MD, PhD
Anterior ischemic optic neuropathy, Magnetic resonance imaging, Normal tension glaucoma, Optic nerve sheath
The pathophysiology of most common forms of acquired optic neuropathy is mysterious, and even increasingly so. For example, elevated IOP is no longer part of the definition of primary open angle glaucoma (POAG). Most cases of normal tension glaucoma (NTG) worldwide are not associate with elevated intraocular pressure (IOP), and progressive vision loss often continues during therapy despite normal or subnormal IOP. But IOP is considered the only modifiable "risk factor" for POAG, so patients are aggressively treated medically and surgically to reduce IOP. The strong association with advancing age, axial myopia, and peripapillary atrophy is unexplained.
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Hot Topics:What's New in the Optic Nerve?
Joseph L. Demer, M.D., Ph.D., Stein Eye Institute and Department of Neurology, University of California, Los Angeles
Spencer S. Eccles Health Sciences Library, University of Utah
2018 North American Neuro-Ophthalmology Society Annual Meeting