Metastatic Orbital Disease with Positive Immunohistochemical test for Breast Cancer without Primary Tumor

Metastatic orbital disease is rare but it must be considered in the differential diagnosis of any patient with known history of cancer, presenting with ophthalmic symptoms. (1-4). Most ocular metastases of breast cancer are located in the choroid, while an extrabulbar localization within the orbit is rare, with only 3-10% of all ocular metastases. Breast carcinoma is the most prevalent primary tumor in metastatic orbital tumor, accounting for 28.5%-58.8% of all metastases followed by lung, prostate, gastrointestinal, kidney and skin (melanoma) cancers (4). Ocular metastasis can be initial manifestation of breast carcinoma, in some data up to 26% of orbital breast metastases (5).