Ganglion cell layer analysis by optical coherence tomography (OCT)

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Identifier EEC_OCT_GCL
Title Ganglion cell layer analysis by optical coherence tomography (OCT)
Subject optical coherence tomography, ganglion cell layer, optic tract, visual field defects
Creator Jonathan A. Micieli, MD, Department of Ophthalmology, Emory University School of Medicine; Valérie Biousse, MD Departments of Ophthalmology and Neurology, Emory University School of Medicine
Description A normal optical coherence tomography (OCT) of the macula is shown (Figure 1) and the various layers of the retina are labelled (Figure 2). The cell bodies of retinal ganglion cells (RGC) are located in the ganglion cell layer (GCL) of the retina and mostly synapse in the lateral geniculate nucleus (Figure 3). Injury to the RGC anywhere along this path may result in cell death and be seen in the retina with OCT. On the Cirrus OCT, the ganglion cell layer and inner plexiform layer are measured together and are referred to as the ganglion cell layer complex (GCC). A normal OCT of the retinal nerve fiber layer (RNFL) and GCC is shown in Figure 5 and a description of each aspect of the result printout is shown in Figure 6. A case of a 54-year-old woman with a right incongruous homonymous hemianopia due to an ischemic stroke affecting the left optic tract is shown as a case study (Figures 7 and 8). Three case examples of segmentation errors are shown in patients with central serous chorioretinopathy (Figure 9), epiretinal membrane (Figure 10), and disc edema from non-arteritic anterior ischemic optic neuropathy (NAION; Figure 11). A comparison of OCT of the RNFL and GCC is shown in a case of retrograde trans-synaptic degeneration from an occipital lobe stroke. OCT of the GCC provides valuable information when evaluating patients with optic neuropathies, chiasmal or retrochiasmal visual field defects, but must be interpreted with caution since it is prone to segmentation errors.
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2018-01
Format application/pdf
Rights Management Copyright 2017. For further information regarding the rights to this collection, please visit:
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-ophthalmology Virtual Education Library: NOVEL
Language eng
ARK ark:/87278/s6w13432
Setname ehsl_novel_eec
Date Created 2018-01-02
Date Modified 2018-03-05
ID 1290927
Reference URL
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