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Publication Type honors thesis
School or College College of Science
Department Chemistry
Thesis Supervisor Stepehn E. Wright
Honors Advisor/Mentor Ronald O. Ragsdale
Creator Bennett, David Darger
Title Cancer vaccines against avian RNA tumor viruses: Models for a human cancer vaccine
Date 1984-06
Year graduated 1984
Description The objective was to develop a subunit vaccine against sarcoma induced by avian RNA tumor viruses. Envelope glycoproteins were removed from retroviruses Pr-A and Pr-C. The viral components were separated by sedimentation into two fractions: 8 Sand 4-6 S. The immunization capability of these viral subunits were evaluated in terms of tumor development, size and mortality. The 8 S fraction gave the best protection in terms of the three parameters when challenged with a lethal dose of tumor viruses; the protection was subgroup specific. In contrast, the 4-6 S fraction was only partially protective; protection was less subgroup specific. When challenged with inconsistent subgroups, the animals immunized with the 4-6 fraction were as minimally protected as unimmunized controls. This study shows that envelope glycoprotein fractions of the avian RNA tumor viruses can serve as immunogens and that protection is subgroup specific. It further shows that the 8 S subunit is superior to the 4-6 S fraction.
Type Text
Publisher University of Utah
Subject Cancer - Prevention; Vaccines
Language eng
Rights Management (c) David Darger Bennett
Format Medium application/pdf
ARK ark:/87278/s69061s9
Setname ir_htca
ID 1289323
Reference URL https://collections.lib.utah.edu/ark:/87278/s69061s9

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Title Page 9
Setname ir_htca
ID 1289332
Reference URL https://collections.lib.utah.edu/ark:/87278/s69061s9/1289332
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