Role of SIRT1 Activity and pAKT Signaling in ST266-Mediated RGC Neuroprotection (video)

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Identifier 20170403_nanos_sciplatform1_05-video
Title Role of SIRT1 Activity and pAKT Signaling in ST266-Mediated RGC Neuroprotection (video)
Creator Kenneth Shindler, Reas Khan, Kimberly Dine, Larry Brown
Subject Optic neuropathy, Demeylinating disease, Neuro-ophth & systyemic disease ( eg. MS, MG, thyroid)
Description Optic neuritis occurs during multiple sclerosis (MS) and induces retinal ganglion cell (RGC) loss. Thus, neuroprotective therapies are needed. We previously showed that intranasally delivered ST266, the biological secretome of Amnion-derived Multipotent Progenitor cells, attenuated loss of vision and RGCs in experimental optic neuritis, but mechanisms of its actions are not known. Potential mechanisms were examined in the experimental autoimmune encephalomyelitis (EAE) model of MS.
Relation is Part of NANOS Annual Meeting 2017: Scientific Platform I
Contributor Primary Kenneth Shindler
Contributor Secondary Reas Khan, Kimberly Dine, Larry Brown
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2017
Format video/mp4
Source 2017 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Language eng
ARK ark:/87278/s63814f2
Setname ehsl_novel_nam
Date Created 2017-10-13
Date Modified 2017-10-16
ID 1277732
Reference URL https://collections.lib.utah.edu/ark:/87278/s63814f2
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