| Title |
Optic Neuropathy Due to Chronic Lymphocytic Leukemia Proven With Optic Nerve Sheath Biopsy |
| Creator |
Khurrum Khan, BS; Amina I. Malik, MD; Sumayya J. Almarzouqi, MD; Michael L. Morgan, MD; Sushma Yalamanchili, MD; Patricia Chevez-Barrios, MD; Andrew G. Lee, MD |
| Affiliation |
Baylor College of Medicine (KK, AGL), Houston, Texas; Department of Ophthalmology (AIM, SJA, MLM, SY, PC-B, AGL), Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas; Departments of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medical College, Houston, Texas; Department of Ophthalmology and Visual Sciences (AGL), The University of Texas Medical Branch, Galveston, Texas; The University of Texas MD Anderson Cancer Center (AGL), Houston, Texas; The University of Iowa Hospitals and Clinics (AGL), Iowa City, Iowa |
| Abstract |
A 64-year-old woman, with a history of diabetes and melanoma, developed a central retinal vein occlusion (CRVO) in her left eye. On exam, she had severe disc edema with retinal nerve fiber layer thickening, and anterior deformation of the peripapillary retinal pigment epithelium (RPE)/Bruch membrane layer (ppRPE/BM) toward the vitreous on spectral domain optical coherence tomography (SD-OCT) suggesting an optic nerve sheath (ONS) meningioma. Magnetic resonance imaging findings and ONS biopsy later confirmed a metastatic melanoma. This case demonstrates that the shape of the RPE/BM on SD-OCT may aid in the decision to consider imaging in patients with isolated CRVO. |
| Subject |
Antimetabolites, Antineoplastic; Biopsy; Drug Therapy, Combination; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Magnetic Resonance Imaging; Male; Methotrexate; Middle Older people; Optic Nerve; Papilledema; Pyrazoles; Pyrimidines; Spinal Puncture |
| Date |
2016-03 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| ARK |
ark:/87278/s69k85qp |
| Setname |
ehsl_novel_jno |
| ID |
1276458 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s69k85qp |
