Title |
Benign Essential Blepharospasm--There Is More to It Than Just Blinking |
Creator |
Kathleen B. Digre, MD |
Affiliation |
Professor of Neurology and Ophthalmology, Director of Neuro-Ophthalmology, John A. Moran Eye Center, University of Utah School of Medicine; Departments of Neurology (KIL, MMM), Neurosurgery (RCR), and Radiation Oncology (JKR), University of Washington, Seattle, Washington; and Neuro-Ophthalmic Consultants Northwest (SRH), Swedish Medical Center, Seattle, Washington |
Abstract |
High-grade (World Health Organization [WHO] Grade II and III) meningiomas constitute a minority of all meningioma cases but are associated with significant morbidity and mortality, due to more aggressive tumor behavior and a tendency to recur despite standard therapy with resection and radiotherapy. They display a higher degree of vascularity than WHO Grade I meningiomas and produce angiogenic and growth factors, including vascular endothelial growth factor (VEGF). Bevacizumab, a humanized monoclonal antibody against VEGF-A, has been used in the treatment of recurrent or progressive meningiomas resistant to standard therapy. We report a patient with a recurrent left frontotemporal meningioma and associated-vision loss who experienced substantial visual field recovery after 3 cycles of bevacizumab. In addition, we provide a review of the literature regarding the efficacy of bevacizumab in the treatment of recurrent meningiomas. |
Subject |
Animals; Blepharospasm; Blinking; Disease Models, Animal; Humans |
Date |
2015-12 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Publication Type |
Journal Article |
Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
Publisher |
Lippincott, Williams & Wilkins |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
© North American Neuro-Ophthalmology Society |
ARK |
ark:/87278/s6ff7mvb |
Setname |
ehsl_novel_jno |
ID |
1276426 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6ff7mvb |