Introduction and Lessons from Vigabatrin (abstract)

It is often difficult to determine the validity of reported toxicity attributed to a drug and a neuro-ophthalmic abnormality. In some cases, the patient has received combination therapy, such as surgical resection and medical therapy, and in other cases, the complications are not the focus of the report. Some manuscripts consist of individual anecdotal case reports; in others, the evaluation or at least the description of findings is incomplete. Furthermore, the source of the reports in these patients may be varied, including from literature focused on genetics, neurosurgery, neurology, and ophthalmology.