Pseudotumor cerebri without thrombosis in Behçet's Disease

Behçet's disease (BD) is a chronic inflammatory disease affecting small and large, arteries and veins. The most common CNS presentation is brainstem meningoencephalitis involving particularly the diencephalon (parenchymal neuro-BD). Another manifestation of BD is pseudotumor cerebri (PTC) syndrome which is in most cases due to cerebral venous sinus thrombosis (CVST) in these cases it is presumed/accepted that venous hypetension impairs CSF absorption across the arachnoid villi and this results in; CSF hypertension and PTC. However some BD patients with PTC appear not to have CVST. Here we focus on such cases - describe the clinical features and speculate on possible mechanism.