A Case of Third Nerve Palsy following Infliximab Treatment

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Identifier 20170402_nanos_posters_110
Title A Case of Third Nerve Palsy following Infliximab Treatment
Creator Moira R. Altszul
Subject Demeylinating disease, Ocular Motility, Adult strabismus with a focus on diplopia, Neuroimaging
Description Infliximab, a monoclonal anti-TNF α antibody prescribed for treatment of inflammatory and autoimmune diseases (1), may cause neurological adverse reactions, including demyelinating conditions such as multiple sclerosis, optic neuritis, mononeuritis multiplex, Guillain Barré and Miller Fisher syndromes (2, 1, 3, 4, 5). Third nerve palsy with cisternal enhancement with gadolinium on MRI has been reported (6). Whether anti-TNF α blockers unmask preexisting or induces de novo demyelination was addressed by a prospective study. New demyelinating events, which improved with cessation of TNF alfa antagonists and re-emerged with reintroduction of them, supports anti-TNF alfa evoked pathophysiology. Incidence is controversial, some authors conclude it isn ́t clear if TNF alfa antagonists increase demyelinating diseases, while others found 30% increased risk. MRI findings without typical demyelination symptoms is recognized as radiologically isolated syndrome (RIS) (2). If demyelination emerges during treatment, discontinuation of anti TNF alfa is mandatory, with close clinical and MRI follow-up (1) .
Relation is Part of NANOS 2017: Poster Presentations
Contributor Primary Moira R. Altszul
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2017
Format application/pdf
Source 2017 North American Neuro-Ophthalmology Society Annual Meeting
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
ARK ark:/87278/s6gf4njw
Setname ehsl_novel_nam
Date Created 2017-08-21
Date Modified 2017-09-20
ID 1272631
Reference URL https://collections.lib.utah.edu/ark:/87278/s6gf4njw
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