In vitro and in silico tools for studying heterotypic gap junction channel properties

We have developed and tested new in vitro and in silico tools for studying gap junctions at the tissue and single channel level, respectively. We believe this work contributes toward expanding the field of gap junction within the available experimental and computational limits. The PerFlexMEA has the potential to be a potent tool for electrophysiological studies in fibrotic and arrhythmic cardiac tissues. Our in silico studies have revealed a new physiological mechanism that needs to be further investigated in vitro.