Human Astrocyte Matrisome Enhances Neural Network Formation for Use in Transplant Therapy in Cortical Vision Loss

Damage to the occipital cortex disrupts established neural tracks and networks resulting in poor vision processing and blindness. Regeneration of these networks are inherently slow; thus, expediting recovery of synapses in this region is imperative. Here, we demonstrate the use of synapse-promoting mechanisms of astrocytes in human organoid systems to develop rapid and mature neural networks within 28 days.