| Identifier |
20230314_nanos_sciplatform2_04 |
| Title |
Epigenetic Reprogramming- A Novel Gene Therapy to Rejuvenate Injury-Induced Dysfunction of Retinal Ganglion Cells in Optic Neuropathies |
| Creator |
Drenushe Krasniqi; Madhura Shah; Margarete Karg; Yuancheng Lu; David Sinclair; Bruce Ksander; Joseph Rizzo |
| Affiliation |
(DK) (MK) (BK) Schepens Eye Research Institute/ Mass. Eye and Ear; (MS) Massachusetts Eye and Ear; (YL) Sinclair Lab, Harvard Medical School; (DS) Harvard Medical School; (JR) Massachussets Eye and Ear |
| Subject |
Optic Nerve Trauma and Treatment; Optic Neuropathy |
| Description |
NAION (Non-Arteritic Anterior Ischemic Optic Neuropathy) and glaucoma are optic neuropathies with different pathophysiology but a common endpoint, the apoptosis of retinal ganglion cells (RGCs). |
| Date |
2023-03 |
| References |
Lu, Brommer, Tian... Ksander, Sinclair et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020;588(7836):124-129. doi:10.1038/s41586-020-2975-4 Al Aboud , Tupper, Jialal. Genetics, Epigenetic Mechanism. [Updated 2021 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532999/ Hamilton. Epigenetics: principles and practice. Dig Dis. 2011;29(2):130-5. doi: 10.1159/000323874. Epub 2011 Jul 5. PMID: 21734376; PMCID: PMC3134032. |
| Language |
eng |
| Format |
application/pdf |
| Format Creation |
Microsoft PowerPoint |
| Type |
Text |
| Source |
2023 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2023: Scientific Platform Session II: https://novel.utah.edu/collection/NAM/toc/ |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s68479wd |
| Setname |
ehsl_novel_nam |
| ID |
2386594 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s68479wd |
