| Identifier |
20190319_nanos_sciplatform3_04-abstract |
| Title |
MEK Inhibitor Treatment Promotes Retinal Ganglion Cell Preservation without Preventing Retrobulbar Demyelination in Neurofibromatosis Mice |
| Creator |
Steven Stasheff; Francisco Nadal-Nicolas; Wei Li; Miriam Bornhorst; Yuan Zhu |
| Affiliation |
(SS) Neuroscience & Gilbert NF Inst, Children's National Health Sys; National Eye Institute, Washington, District of Columbia; (FN) (WL) (YZ) Retinal Neurophysiology Section, National Eye Institute, Bethesda, Maryland; (MB) (YZ) Gilbert Neurofibromatosis Institute, Children's National Health System, Washington, District of Columbia |
| Subject |
Pediatric Neuro-Ophthalmology; Neuro-Ophth & Systyemic Disease (eg. MS, MG, Thyroid); Genetic; Disease; Chemotherapy and Radiation Injury; Higher Visual Functions |
| Description |
To better understand the disparity frequently seen between optic pathway glioma (OPG) characteristics and visual loss among young children with neurofibromatosis type 1 (NF1), we extend our previous findings of anatomic, physiologic, and behavioral abnormalities in an established animal model. We now report differential effects of treatment targeting the MAPK/ERK cellular pathway: 1) preserving retinal ganglion cell (RGC) number, and yet 2) failing to ameliorate demyelination of the retrobulbar optic nerve. |
| Date |
2019-03 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2019 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS 2019: Scientific Platform III |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2019. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6wh74p1 |
| Setname |
ehsl_novel_nam |
| ID |
1422863 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6wh74p1 |
