Novel Autoantibodies in Sjogren's Syndrome. Early recognition of this Autoimmune state prior to Neurological Complications

The neurological complications of Sjogren's syndrome can be severe. This inflammatory condition is often considered 'ruled out' in patients whose initial lab testing for anti-Ro and anti-La is negative. Novel autoantibodies have been discovered that are positive in; many cases prior to the SSA ad SSB titers ever turning positive. These autoantibodies, which occur early in the course of SS, include Anti-salivary gland protein 1 (SP1), Anti-carbonic anhydrase 6 (CA6) and anti-parotid secretory protein (PSP).